Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity
نویسندگان
چکیده
منابع مشابه
Dengue-yellow fever sera cross-reactivity; challenges for diagnosis.
OBJECTIVE The Flavivirus genera share epitopes inducing cross-reactive antibodies leading to great difficulty in differentially diagnosing flaviviral infections. This work was aimed at evaluating the complexity of dengue and yellow fever serological differential diagnosis. MATERIAL AND METHODS Dengue antibody capture ELISA and a yellow fever neutralisation test were carried out on 13 serum sa...
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INTRODUCTION Dengue fever is endemic in developing nations worldwide with as many as 500,000 annual cases of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). A prompt and accurate diagnosis early in the disease course is essential for prompt identification and treatment of severe complications of the dengue virus infection (DVI). We identified cross-reactivity of a rapid IgM test...
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Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of th...
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Dengue fever is considered the most important arthropod-borne viral diseases in terms of morbidity and mortality. An accurate and efficient diagnosis of dengue plays an important role in case confirmation. The virus may be isolated during the viremic phase (within day 5 of illness), from serum, plasma and peripheral blood mononuclear cells. Enzyme linked immunoassay (ELISA) has demonstrated the...
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Brucellosis and Dengue fever can present with acute febrile illness with other nonspecific symptoms and share common haematological and biochemical abnormalities making their clinical differentiation a diagnostic challenge. We present two cases admitted with acute febrile illness and other nonspecific symptoms. In both patients diagnosis of brucellosis was confirmed by positive blood culture an...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.01055